By Joseph Mercola via thevaccinereaction
When it comes to vaccine safety, a complaint that I’ve frequently expressed is the lack of credible studies comparing vaccinated and unvaccinated populations.
At best, we’ve had vaccination surveys1 based on self-reported data,2 and while that evidence strongly suggested unvaccinated children experience better health and fewer health problems, they were dismissed by most public health officials as unimportant. There are also published studies showing annual influenza vaccination takes its toll on your health,3 4 5 6 and may do more harm than good in the long term.
Now, two pilot studies led by Anthony Mawson,7 an interdisciplinary epidemiologist and social scientist with a doctorate in public health, have helped to shed some light on the topic.
The gold standard in scientific research is replication and, while the conclusions of these studies need to be replicated using other data sources, they are another piece of evidence showing there are negative health outcomes for vaccinated children, and that unvaccinated children are actually healthier. It’s a good start, and it’s important to know these studies exist.
Vaccination Schedule May Place Preemies at Increased Risk of Neurodevelopmental Disorders
The first paper,8 published in the peer-reviewed open-access Journal of Translational Science (April 24, 2017), is a cross-sectional study of 6- to 12-year-olds exploring the association between preterm birth, vaccination and neurodevelopmental disorders, using data from both vaccinated and unvaccinated populations. Preemies receive the same vaccines and number of doses recommended by the federal childhood vaccination schedule as full-term babies, and on the same time schedule.
Data show anywhere from 8 to 27 percent of extremely preterm infants develop autism spectrum disorder (ASD). Premature birth is a known risk factor for neurodevelopmental problems of varying severity, yet prior to this study, the impact of the vaccination schedule on this risk had never been assessed. Not surprisingly, the results suggest the federally recommended childhood vaccination schedule may be inappropriate for premature infants. The abstract reads, in part:
The possible role of vaccination in neurodevelopmental disorders (NDD) among premature infants is unknown, in part because pre-licensure clinical trials of pediatric vaccines have excluded ex-preterm infants. This paper explores the association between preterm birth, vaccination and NDD, based on a secondary analysis of data from an anonymous survey of mothers, comparing the birth history and health outcomes of vaccinated and unvaccinated homeschool children 6 to 12 years of age. A convenience sample of 666 children was obtained, of which 261 (39 percent) were unvaccinated, 7.5 percent had an NDD … and 7.7 percent were born preterm. No association was found between preterm birth and NDD in the absence of vaccination … However, vaccination coupled with preterm birth was associated with increasing odds of NDD, ranging from 5.4 [percent] compared to vaccinated but non-preterm children, to 14.5 [percent] compared to children who were neither preterm nor vaccinated. The results of this pilot study suggest clues to the epidemiology and causation of NDD but question the safety of current vaccination practices for preterm infants. Further research is needed to validate and investigate these associations in order to optimize the impact of vaccines on children’s health.
Vaccination Linked to Higher Risk of NDD Among Full-Term Babies Too
The fact that no link was found between premature birth and NDDs among the unvaccinated raises the disturbing possibility that the vaccination schedule for premature babies could be responsible for the neurological disorders some premature babies exhibit, which have been previously assumed to be simply a result of premature birth.
This provocative possibility is further strengthened by the finding that vaccination was, in fact, linked with a higher risk of NDD among full-term children. As noted in the paper, aside from preemies being excluded from pre-licensure vaccine trials, another reason this issue has never been formally investigated is “the assumed overall safety of vaccinations.” The results reveal why assuming safety uses seriously flawed logic.
Another powerful example of why safety should never be assumed are West African studies that revealed a high titer measles vaccine interacted with the diphtheria-tetanus-pertussis (DTP) vaccine and resulted in a 33 percent increase in infant mortality.9 Those shocking findings led to the withdrawal of that measles vaccine. But what would have happened had those studies never been done? Clearly, we need more like them.
The fact is, all vaccines need to be carefully evaluated not only individually for long-term safety, but also for synergistic toxicity when the vaccine is given in combination with other vaccines and given repeatedly over a period of time. In 2013, a physician committee at the Institute of Medicine (IOM), National Academy of Sciences, pointed out that the current federally recommended childhood vaccine schedule for infants and children from birth to age 6 had not been adequately studied for safety.10
The physicians and IOM staff only were able to identify fewer than 40 studies published in the previous 10 years that addressed the 0- to 6-year-old child vaccine schedule.
The IOM committee concluded there was not enough scientific evidence to determine whether or not the numbers of doses and timing of federally recommended vaccines children receive in the first six years of life are associated with health problems in premature infants or the development of chronic brain and immune system disorders that affect a child’s intellectual development, learning, attention, communication and behavior, such as ADD/ADHD, learning disabilities and autism.
This is why Mawson’s pilot studies have great value and why many more studies comparing the health of vaccinated and unvaccinated children must be conducted. As noted by the IOM’s11 2013 “Childhood Immunization Schedule and Safety” report, studies are needed to examine the:
Long-term cumulative effects of vaccines
Timing of vaccination in relation to the age and health of the child
Effects of the total load or number of vaccines given at one time
Effect of vaccine ingredients in relation to health outcomes
Biological mechanisms of vaccine-associated injury
It’s also important for people to understand that the Vaccine Safety Datalink (VSD) database, which the U.S. Centers for Disease Control and Prevention (CDC) uses to publish studies concluding that vaccine risks are negligible or nonexistent, is a closed database.12
The patient medical records data in the VSD is obtained from HMOs that are paid by the CDC to participate. VSD medical records data is not readily available to researchers, if at all, making the CDC’s conclusions virtually impossible to replicate and verify. This simply isn’t right because it prevents independent confirmation of the CDC’s conclusions that vaccine risks are minimal and the government’s early childhood vaccine schedule is safe, thereby contributing to the poor evidence base for or against vaccine safety.
Summary of Findings
The authors of the recently published study on premature birth, vaccination and neurodevelopmental disorders summarize their findings as follows:
Preterm birth without vaccination was not associated with NDD
Term birth with vaccination was associated with a 2.7-fold (270 percent) increase in the odds of NDD
Preterm birth with vaccination was associated with a 5.4-fold increase in the odds of NDD compared to the odds of NDD given term birth and vaccination
Preterm birth with vaccination was associated with a 12.3-fold increased odds of NDD compared to preterm birth without vaccination (not technically significant because no child in the sample with an NDD was both preterm and unvaccinated)
Preterm birth with vaccination was associated with a 14.5-fold increased odds of NDD compared to being neither preterm nor vaccinated
In adjusted regression analyses, the association between vaccination and NDD remained even after taking other contributing factors into account. In the final adjusted model, the combination of preterm birth with vaccination was associated with a 660 percent increased odds of NDD, “suggesting a synergistic effect.” How do the authors explain these findings? A “tentative hypothesis” for why preemies are at increased risk for NDD was associated with receipt of one or more vaccines. The authors concluded:
Receipt of one or more vaccines could precipitate NDD in some preterm infants by exacerbating a preexisting inflammatory state associated with prematurity, leading to hepatic encephalopathy and hypoxic-ischemic brain damage. Impaired liver function is a predisposing factor for preterm birth and the latter is associated with increased risks of hypoxic-ischemic brain injury … Consistent with this hypothesis, liver dysfunction is reported as an adverse effect of vaccination and as a feature of children with autism. Furthermore, hyperbilirubinemia is associated with hypoxic-ischemic brain damage and is a feature of the preterm infant as well as children with later-onset cognitive disorders and ASD.
Pilot Study Compares Health of Vaccinated and Unvaccinated Children
The second paper,13 published on the same issue of the journal, was a pilot study “designed as a cross-sectional survey of homeschooling mothers on their vaccinated and unvaccinated biological children ages 6 to 12,” in which a wider range of health outcomes was evaluated. The results showed vaccinated children were:
[S]ignificantly more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD (that is, ASD, ADHD and/or a learning disability). The vaccinated were also more likely to use allergy medication, to have had myringotomies with tube placement, visited a doctor for a health problem in the previous year, and been hospitalized at some time in the past.
More specifically, the results showed vaccinated children (whether partially or fully vaccinated) were significantly more likely than the unvaccinated to have been diagnosed with:
Otitis media (19.8 percent versus 5.8 percent)
Pneumonia (6.4 percent versus 1.2 percent
Allergic rhinitis (10.4 percent versus 0.4 percent) as well as other allergies (22.2 percent versus 6.9 percent)
Eczema/atopic dermatitis (9.5 percent versus 3.6 percent)
Any chronic illness (44 percent versus 25 percent)
1 Vaccineinjury.info. 2 Enriquez. Journal of Allergy and Clinical Immunology 2005; 115(4): 737-734. 3 Vaccine December 1998;16(20):1929-32. 4 STAT News November 11, 2015. 5 CIDRAP April 6, 2010. 6 Science Daily May 20, 2009. 7 Jsums.edu, Mawson Bio. 8 Journal of Translational Science April 24, 2017, DOI: 10.15761/JTS.1000187. 9 BMJ 344: e3769. 10 Institute of Medicine (2013) The childhood immunization schedule and safety: Stakeholder concerns, scientific evidence and future studies. 11 Ibid. 12 Institute of Medicine (2005) Vaccine Safety Research, Data Access and Public Trust. 13 Journal of Translational Science April 24, 2017, DOI: 10.15761/JTS.1000186.
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